PFT: Raiders have $45 million in dead money

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Recently, free-agent linebacker Brendon Ayanbadejo has been backpedaling more than a cornerback.

After suggesting this his support for same-sex marriage was a factor in his release by the Ravens, Ayanbadejo quickly said it wasn?t.? Now, not long after explaining that four gay players are considering coming out at the same time, Ayanbadejo says they aren?t.

Via Outsports.com, that was the upshot of Ayanbadejo?s Friday night appearance with Anderson Cooper of CNN.

?No, actually, what it is is, is there are organizations I?m in contact with, and there are individuals I?m in contact with and collectively we know of some gay players,? Ayanbadejo said when asked if he knows the names of the four gay players who are considering coming out.? ?And these players, some of them are anonymous, some of them we know who they are, but their identity is super secret and nobody wants to reveal who they are, and some of them don?t want to reveal who they are, rightfully so because it?s entirely up to them what they are going to do.

?What we want to facilitate is getting them all together so they can lean on each other, so they can have a support group.? And potentially it?s possible, it?s fathomable, that they could possibly do something together, break a story together.?

Apart from Ayanbadejo?s chronic inability to get his facts straight, he has an increasingly obvious desire to see one or more gay players come out. ?Gay players wrestling with this intensely personal decision easily could perceive that they are merely pawns in a much broader agenda being driven by straight players and/or members of the media who believe that the time has come for closeted gay players to be openly gay.

As former NFL player Wade Davis, who is openly gay, tells Outsports.com, ?The problem is that you have straight people speaking on the behalf of these closeted gay athletes, instead of letting the gay athletes speak for themselves.?

There?s a fine line between providing support and applying pressure.? While having multiple gay players come out at once would reduce the distraction created by one gay player coming out, if none of them choose to come out, that?s their business.

Ultimately, we believe people should be allowed to be who they are, and who they choose to be.? That includes straight, gay, and closeted.? If a gay player simply doesn?t want to come out, that?s his prerogative ? and no one gay or straight should be trying to get him to do something he doesn?t want to do.

Source: http://profootballtalk.nbcsports.com/2013/04/06/mckenzies-still-a-year-away-from-rebuilding-raiders/related/

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Bros Asks Students at the University of Wisconsin-Madison ?Why A**holes Always Finish First?

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Source: http://www.brobible.com/college/article/university-of-wisconsin-madison-interview

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Staff Cuts At Press Communications/Monmouth-Ocean, NJ ...

Downsizing

ALL ACCESS has heard rumors of significant staff downsizing at the PRESS COMMUNICATIONS/MONMOUTH-OCEAN, NJ cluster. Confirmed casualties are Station Manager, Dir./Programming and WBHX morning host MIKE FITZGERALD; WWZY mornings/WBHX afternoons/WKMK-KHTG nights RANDY DAVIS; News Dir. AL BROOKS and WWZY nights SHELLI COLE.

More details to come.

? see more Net News

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Source: http://www.allaccess.com/net-news/archive/story/117156/staff-cuts-at-press-communications-monmouth-ocean-

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Biden Holds Off on Donating Salary (ABC News)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/297040154?client_source=feed&format=rss

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Remote reefs can be tougher than they look

Friday, April 5, 2013

Remote reefs can be tougher than they look Western Australia's Scott Reef has recovered from mass bleaching in 1998.

Isolated coral reefs can recover from catastrophic damage as effectively as those with nearby undisturbed neighbours, a long-term study by marine biologists from the Australian Institute of Marine Science (AIMS) and the ARC Centre of Excellence for Coral Reef Studies (CoECRS) has shown.

Scott Reef, a remote coral system in the Indian Ocean, has largely recovered from a catastrophic mass bleaching event in 1998, according to the study published in Science today.

The study challenges conventional wisdom that suggested isolated reefs were more vulnerable to disturbance, because they were thought to depend on recolonisation from other reefs. Instead, the scientists found that the isolation of reefs allowed surviving corals to rapidly grow and propagate in the absence of human interference.

Australia's largest oceanic reef system, Scott Reef, is relatively isolated, sitting out in the Indian Ocean some 250 km from the remote coastline of north Western Australia (WA). Prospects for the reef looked gloomy when in 1998 it suffered catastrophic mass bleaching, losing around 80% of its coral cover. The study shows that it took just 12 years to recover.

Spanning 15 years, data collected and analysed by the researchers shows how after the 1998 mass bleaching the few remaining corals provided low numbers of recruits (new corals) for Scott Reef. On that basis recovery was projected to take decades, yet within 12 years the cover and diversity of corals had recovered to levels similar to those seen pre-bleaching.

"The initial projections for Scott Reef were not optimistic," says Dr James Gilmour from AIMS, the lead author on the publication, "because, unlike reefs on the Great Barrier Reef, there were few if any reefs nearby capable of supplying new recruits to replenish the lost corals at Scott Reef.

"However, the few small corals that did settle at Scott Reef had excellent rates of survival and growth, whereas on many nearshore reefs high levels of algae and sediment, and poor water quality will often suppress this recovery.

"We know from other studies that the resilience of reefs can be improved by addressing human pressures such as water quality and overfishing," says Dr Gilmour. "So it is likely that a key factor in the rapid recovery at Scott Reef was the high water clarity and quality in this remote and offshore location."

Dr Andrew Heyward, Principal Research Scientist at AIMS, highlights another conclusion from their findings.

"Previously we've tended to factor proximity to other reefs as a key attribute when estimating the resilience of a reef following a major disturbance, but our data suggests that given the right conditions, reefs might do much of the recovery by themselves." This finding could have implications for the management of marine protected areas.

In their publication the team also draws attention to the important role played by climate change in the longer-term prospects for coral reefs, as Prof Morgan Pratchett of CoECRS explains.

"While it is encouraging to see such clear recovery, we need to be mindful of the fact that the coral recovery at Scott Reef still took over a decade. If, as the climate change trend suggests, we start to see coral bleaching and other related disturbances occurring more frequently, then reefs may experience a ratcheting down effect, never fully recovering before they suffer another major disturbance.

"By preventing illegal fishing and enhancing water quality on coral reefs in all regions we will give these reefs a greater capacity to recover from major disturbances."

The highly detailed, long-term data set makes Scott Reef the best studied reef in Australia's Indian Ocean territory. The study provides valuable new perspectives on ecosystem function and resilience of coral reefs situated in the northwest Australia, and in other contexts such as the Great Barrier Reef, and illustrates the importance of AIMS' research collaborations with its industry partners.

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The paper "Recovery of an isolated coral reef system following severe disturbance", by J. P. Gilmour, L. D. Smith, A. J. Heyward, A. H. Baird and M. S. Pratchett appears online in Science on Friday, 5th April, 2013.

ARC Centre of Excellence in Coral Reef Studies: http://www.coralcoe.org.au/

Thanks to ARC Centre of Excellence in Coral Reef Studies for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 36 time(s).

Source: http://www.labspaces.net/127614/Remote_reefs_can_be_tougher_than_they_look

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Shutting down DNA construction: How senescence halts growth of potential cancers

Friday, April 5, 2013

Researchers from The Wistar Institute explain a new molecular mechanism behind the phenomenon of oncogene-induced senescence. By depriving the cell of the ability to make new nucleotides?the building blocks of DNA molecules?cells can suppress cancer development by forcing a damaged cell into a senescent state, where the cell remains alive yet cannot reproduce.

According to the researchers, their findings may offer a new strategy to strengthen the effects of anti-cancer drugs and chemotherapies.

Their results, which appear in the April 25 issue of Cell Reports (available online now), show how a senescent cell may become cancerous if supplied with a new source of nucleotides. Their experiments were performed using nevi?the technical term for moles?and melanoma cells, but the underlying mechanism may apply to all human cells.

"Oncogene-induced senescence is an automatic mechanism that arrests the growth of normal cells when an oncogene or cancer-causing gene is activated to prevent the progression of these cells into cancer," said Rugang Zhang, Ph.D., associate professor in The Wistar Institute Cancer Center's Gene Expression and Regulation program. "We identified how an oncogene can set senescence into motion by suppressing RRM2, an enzyme necessary for producing nucleotides."

Without the nucleotide building blocks of DNA, Zhang says, the cell cannot multiply. When new sources of nucleotides are introduced, however, the cell goes into overdrive, becoming cancerous.

Zhang offers an analogy comparing senescence to a construction site, where workers continue to build as long as they have a steady supply of bricks. When an oncogene is activated, it is like hiring an excess of workers. A normal cell's typical defense mechanism is to cancel orders for new bricks. When all the excess workers quickly run through their supply of bricks, the construction site shuts down. This is essentially senescence. If you suddenly flood the site with new building materials, the workers go into overdrive, building wildly without supervision. In the case of cancer, this causes the cells to put DNA building into overdrive?starting the endless cycles of cell growth and division that are the hallmark of cancer.

Wistar's Katherine Aird discusses the Zhang Lab's findings on the mechanics of oncogene-induced senescence. In the April 25, 2013 issue of the journal Cell Reports, they demonstrate how DNA damage can cause a cell to become senescent, a state where growth is halted. (A mole on your skin is an example of a senescent cell you see every day.) They show how this happens as cells suppress the ability to generate nucleotides (the building blocks of DNA). When you supply the cell with new sources of nucleotides, the cell will go into a frenzy of multiplication -- a hallmark of cancer.

Credit: The Wistar Institute

To explore how oncogene-induced senescence works, Zhang and his colleagues compared human moles (essentially, pre-cancerous lesions in a senescent state) to cancerous melanoma cells. They found that stable, senescent cells experienced a dramatic decrease in the available number of nucleotides. This was linked to the suppression of RRM2, a gene whose protein is important for making nucleotides. Further, they linked this RRM2 suppression to mutations in BRAF or NRAS, proteins that control the cycle of growth and replication within cells that have been labeled "oncogenes" because their mutation is linked to melanoma and other cancers. Indeed, they report that melanoma patients with high levels of RRM2 fare worse, overall.

Since cells that lacked nucleotides became senescent, the researchers wondered what would happen if they resupplied the cell with nucleotides?in essence, providing eager workers more bricks. They found that, even in cells with an inactive RRM2 gene, the cell rapidly resumed growing and dividing. Such an event in moles, for example, could be what causes melanoma.

"Moles are probably the most visible example of the effect of oncogene-induced senescence in human cells," said Katherine M. Aird, Ph.D., lead author of the study and postdoctoral fellow in the Zhang laboratory at Wistar. "The cells within a mole may have arrested growth, but they are still alive, and may regain activity, even turning cancerous. That is why your dermatologist might tell you to keep an eye on a seemingly benign mole, as changes in its size, color or shape could indicate that it is no longer benign."

According to Aird, if you could stabilize senescence, perhaps by targeting RRM2, it could put the brakes on even drug-resistant cells.

"This mechanism also suggests a strategy for patient therapy," Aird explained. "If we can decrease RRM2 activity, it could force tumor cells into a stronger senescent state, perhaps improving the effectiveness of chemotherapy or targeted drugs."

###

The Wistar Institute: http://www.wistar.org

Thanks to The Wistar Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 23 time(s).

Source: http://www.labspaces.net/127608/Shutting_down_DNA_construction__How_senescence_halts_growth_of_potential_cancers

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Putin critic who faces trial says he wants to be president

By Steve Gutterman

MOSCOW (Reuters) - A Russian opposition leader said he wanted to become president and would do everything in his power to put Vladimir Putin in jail, in a defiant message days before he goes on trial on theft charges he says are politically motivated.

Alexei Navalny, an anti-corruption blogger who was a leader of the biggest opposition protests of Putin's 13-year rule last year, is to go on trial on April 17.

The 36-year-old says the case is part of a Kremlin campaign to silence dissent. He faces up to 10 years in jail if found guilty of stealing 16 million roubles ($512,000) worth of timber from a state firm in 2009.

He has denied wrongdoing in the timber case as well as separate cases in which he is accused of defrauding a mail transport company and stealing funds from a political party, describing the allegations as "absurd".

"I want to become president," Navalny told Internet and cable TV channel Dozhd late on Thursday. "I want to change the way people live in this country, I want to change the system of government in this country."

He said he would do to all he could to see Putin and wealthy businessmen with longstanding ties to the president jailed. "For me they are all links in the chain of loathsome, thieving authorities," he said.

Russia's next presidential election is in 2018. Putin, who began a six-year term last May, has not ruled out seeking re-election.

Navalny popularized the label "party of crooks and thieves" for Putin's ruling United Russia party, and it became a slogan at protests that erupted after a December 2011 parliamentary election marred by allegations of widespread fraud.

The Kremlin denies the charges against Navalny are politically motivated.

Western governments and rights groups have expressed concern over the prosecution of government critics such as the punk band Pussy Riot, as well as laws tightening controls on advocacy groups and street protests.

(Editing by Pravin Char)

Source: http://news.yahoo.com/putin-critic-faces-trial-says-wants-president-184019699.html

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